Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …

OBJECTIVE Streptozotocin (STZ) is the most widely used diabetogenic agent in animal
models of islet transplantation. However, the immunomodifying effects of STZ and the …

Glaucoma is a leading cause of irreversible blindness. Injury of retinal ganglion cells (RGCs)
accounts for visual impairment of glaucoma. Here, we report rapamycin protects RGCs from …

Introduction Prophylactic strategies to prevent the development of allergies by establishing
tolerance remain an unmet medical need. We previously reported that the transfer of …

Regulatory T cells (Tregs) play a critical role in maintaining self-tolerance and in containing
allo-immune responses in the context of transplantation. Recent advances yielded the …

Worldwide, there is a constant rise in the number of patients with end-stage organ failure in
critical need for transplants, but the number of organs/cells available from deceased or living …

The immune system is comprised of several CD4+ T regulatory (Treg) cell types, of which
two, the Foxp3+ Treg and T regulatory type 1 (Tr1) cells, have frequently been associated …

The immunosuppressive drug rapamycin (RAPA) has been used clinically to prevent graft
rejection since 1999 because of its suppressive effects on T cell activation and proliferation …

Novel concepts employing autologous, ex vivo expanded natural regulatory T cells (nTreg)
for adoptive transfer has potential to prevent organ rejection after kidney transplantation …