Current status of xenotransplantation research and the strategies for preventing xenograft rejection
Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
Xenotransplantation: back to the future?
The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …
Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells
OBJECTIVE Streptozotocin (STZ) is the most widely used diabetogenic agent in animal
models of islet transplantation. However, the immunomodifying effects of STZ and the …
models of islet transplantation. However, the immunomodifying effects of STZ and the …
Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model
W Su, Z Li, Y Jia, Y Zhuo - PloS one, 2014 - journals.plos.org
Glaucoma is a leading cause of irreversible blindness. Injury of retinal ganglion cells (RGCs)
accounts for visual impairment of glaucoma. Here, we report rapamycin protects RGCs from …
accounts for visual impairment of glaucoma. Here, we report rapamycin protects RGCs from …
Adoptive transfer of allergen-expressing B cells prevents IgE-mediated allergy
L Prickler, U Baranyi, K Mengrelis, AM Weijler… - Frontiers in …, 2023 - frontiersin.org
Introduction Prophylactic strategies to prevent the development of allergies by establishing
tolerance remain an unmet medical need. We previously reported that the transfer of …
tolerance remain an unmet medical need. We previously reported that the transfer of …
Costimulation blockade and Tregs in solid organ transplantation
M Muckenhuber, T Wekerle, C Schwarz - Frontiers in Immunology, 2022 - frontiersin.org
Regulatory T cells (Tregs) play a critical role in maintaining self-tolerance and in containing
allo-immune responses in the context of transplantation. Recent advances yielded the …
allo-immune responses in the context of transplantation. Recent advances yielded the …
[HTML][HTML] Xenotransplantation: where do we stand in 2016?
GLY Puga, R Rieben, L Bühler, HJ Schuurman… - Swiss medical …, 2017 - smw.ch
Worldwide, there is a constant rise in the number of patients with end-stage organ failure in
critical need for transplants, but the number of organs/cells available from deceased or living …
critical need for transplants, but the number of organs/cells available from deceased or living …
[HTML][HTML] Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen
N Gagliani, T Jofra, A Valle, A Stabilini… - American Journal of …, 2013 - Elsevier
The immune system is comprised of several CD4+ T regulatory (Treg) cell types, of which
two, the Foxp3+ Treg and T regulatory type 1 (Tr1) cells, have frequently been associated …
two, the Foxp3+ Treg and T regulatory type 1 (Tr1) cells, have frequently been associated …
The effects of rapamycin on regulatory T cells: its potential time-dependent role in inducing transplant tolerance
J Shan, L Feng, Y Li, G Sun, X Chen, P Chen - Immunology Letters, 2014 - Elsevier
The immunosuppressive drug rapamycin (RAPA) has been used clinically to prevent graft
rejection since 1999 because of its suppressive effects on T cell activation and proliferation …
rejection since 1999 because of its suppressive effects on T cell activation and proliferation …
[HTML][HTML] Ex vivo expanded natural regulatory T cells from patients with end-stage renal disease or kidney transplantation are useful for autologous cell therapy
S Landwehr-Kenzel, A Zobel, H Hoffmann… - Kidney International, 2018 - Elsevier
Novel concepts employing autologous, ex vivo expanded natural regulatory T cells (nTreg)
for adoptive transfer has potential to prevent organ rejection after kidney transplantation …
for adoptive transfer has potential to prevent organ rejection after kidney transplantation …