Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

The endothelium is immunoregulatory in that inhibiting the function of vascular adhesion
molecules blocks leukocyte recruitment and thus tissue inflammation. The function of …

Obesity is a principal causative factor in the development of metabolic syndrome. Here we
report that increased oxidative stress in accumulated fat is an important pathogenic …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Flavocytochrome b 558 is the catalytic core of the respiratory-burst oxidase, an enzyme
complex that catalyzes the NADPH-dependent reduction of O 2 into the superoxide anion O …

The importance of reactive oxygen species (ROS) in vascular physiology and pathology is
becoming increasingly evident. All cell types in the vascular wall produce ROS derived from …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …

We previously reported enhanced expression of the p67 phox and gp91 phox components
of NAD (P) H oxidase in angiotensin (Ang) II–induced hypertension, suggesting de novo …

Background With the rising age of the global population, the incidence rate of cardiovascular
and cerebrovascular diseases (CCVDs) is increasing, which causes serious public health …

Apocynin is a naturally occurring methoxy‐substituted catechol, experimentally used as an
inhibitor of NADPH‐oxidase. It can decrease the production of superoxide (O 2−) from …