The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …

High-throughput sequencing technologies have allowed many gene locus–level molecular
biology assays to become genome-wide profiling methods. DNA-cleaving enzymes such as …

Genomic footprinting has emerged as an unbiased discovery method for transcription factor
(TF) occupancy at cognate DNA in vivo. A basic premise of footprinting is that sequence …

DNase-seq allows nucleotide-level identification of transcription factor binding sites on the
basis of a computational search of footprint-like DNase I cleavage patterns on the DNA …

Abstract Rationale: Overexpression of NAD (P) H: quinone oxidoreductase 1 (NQO1) is
associated with tumor cell proliferation and growth in several human cancer types. However …

Salamanders have the remarkable ability to functionally regenerate after spinal cord
transection. In response to injury, GFAP+ glial cells in the axolotl spinal cord proliferate and …

Abstract Background and Aims Alteration in intestinal permeability is the main factor
underlying the pathogenesis of many diseases affecting the gut, such as inflammatory bowel …

Human skin is a primary target of oxidative stress from reactive oxygen species (ROS)
generated from both extrinsic and intrinsic sources. Oxidative stress inhibits the production …

Reconstructing gene regulatory networks (GRNs) from gene expression data is a
challenging problem. Existing GRN reconstruction algorithms can be broadly divided into …

The inducible proto-oncogenic (c-Fos: c-Jun)/AP-1 transcription complex binds 12-O-
tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) in its target genes. It is …