The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor
expressed in myeloid cells, with crucial functions in antifungal responses. However, over …

Over the last decade, invasive fungal infections have emerged as a growing threat to human
health worldwide and novel treatment strategies are urgently needed. In this context …

Curdlan have been investigated for a long time. This β (1→ 3)-glucan has distinctive thermal
gel-forming character and is edible, which was approved by the Food and Drug …

Macrophages are important innate immune defense system cells in the fight against
bacterial and fungal pathogenic infections. They exhibit significant plasticity, particularly with …

Sight depends on the passage of light through the transparent cornea and being focused on
the fovea. Its exposed position renders it vulnerable to microbial infection. The cornea has …

Polysaccharides are naturally occurring biological macromolecules that are envisaged as
promising substitutes of non-degradable polymers due to their outstanding inherent …

This study evaluated the immunostimulatory activity of curdlan oligosaccharides (GOS) in
cyclophosphamide (CTX)-induced immunosuppressed mice and in RAW264. 7 cells. GOS …

Abstract Curdlan, a β-1, 3-glucan isolated from Alcaligenes faecalis, is an agonist of dectin-1
in various immune cells, including dendritic cells (DCs). However, whether curdlan also …

6-Amino-6-deoxy-curdlan is a promising nucleic acid carrier that efficiently delivers plasmid
DNA as well as short interfering RNA (siRNA) to various cell lines. The highly reactive C6 …

Fungal keratitis is a potentially blinding infection of the cornea that afflicts diverse patient
populations worldwide. The development of better treatment options requires a more …