Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

Once deemed heretical, emerging evidence now supports the notion that the inheritance of
acquired characteristics can occur through ancestral exposures or experiences and that …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has
been clear for decades that additional epigenetic information can be passed on to future …

The small RNA payload of mammalian sperm undergoes dramatic remodeling during
development, as several waves of microRNAs and tRNA fragments are shipped to sperm …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

Mammalian sperm RNA is increasingly recognized as an additional source of paternal
hereditary information beyond DNA. Environmental inputs, including an unhealthy diet …

BACKGROUND Spermatogenesis generates a small and highly specialised type of cell that
is apparently incapable of transcription and translation. For many years, this dogma was …

The most fundamental process for the perpetuation of a species is the transfer of information
from parent to offspring. Although genomic DNA contributes to the majority of the …