Pharmacology of cannabinoid CB1 and CB2 receptors
RG Pertwee - Pharmacology & therapeutics, 1997 - Elsevier
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …
Cannabis: pharmacology and toxicology in animals and humans
IB Adams, BR Martin - Addiction, 1996 - Wiley Online Library
Cannabis is one of the most widely used drugs throughout the world. The psychoactive
constituent of cannabis, δ9‐tetrahydrocannabinol (δ9‐THC), produces a myriad of …
constituent of cannabis, δ9‐tetrahydrocannabinol (δ9‐THC), produces a myriad of …
Cannabinoid physiology and pharmacology: 30 years of progress
AC Howlett, CS Breivogel, SR Childers… - …, 2004 - Elsevier
Δ9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528 …
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528 …
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
V Chevaleyre, PE Castillo - Neuron, 2003 - cell.com
Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically
dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy …
dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy …
Cannabinoid receptor signaling
AC Howlett - Cannabinoids, 2005 - Springer
The cannabinoid receptor family currently includes twotypes: CB 1, characterized in
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
B Kola, E Hubina, SA Tucci, TC Kirkham… - Journal of Biological …, 2005 - ASBMB
Endocannabinoids and ghrelin are potent appetite stimulators and are known to interact at a
hypothalamic level. However, both also have important peripheral actions, including …
hypothalamic level. However, both also have important peripheral actions, including …
Neuropsychological functioning in adolescent marijuana users: subtle deficits detectable after a month of abstinence
KL Medina, KL Hanson, AD Schweinsburg… - Journal of the …, 2007 - cambridge.org
In adults, studies examining the long-lasting cognitive effects of marijuana use demonstrate
subtle deficits in attention, executive function, and memory. Because neuromaturation …
subtle deficits in attention, executive function, and memory. Because neuromaturation …
Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system
JM McPartland, GW Guy, V Di Marzo - PloS one, 2014 - journals.plos.org
Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …
Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
Deficits in cognitive functioning and flexibility are seen following both chronic stress and
modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether …
modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether …
Blunted psychotomimetic and amnestic effects of Δ-9-tetrahydrocannabinol in frequent users of cannabis
DC D'souza, M Ranganathan, G Braley… - …, 2008 - nature.com
Cannabis is one of the most widely used illicit substances and there is growing interest in
the association between cannabis use and psychosis. Delta-9-Tetrahydrocannabinol (Δ-9 …
the association between cannabis use and psychosis. Delta-9-Tetrahydrocannabinol (Δ-9 …