Pharmacology of cannabinoid CB1 and CB2 receptors

RG Pertwee - Pharmacology & therapeutics, 1997 - Elsevier
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …

Cannabis: pharmacology and toxicology in animals and humans

IB Adams, BR Martin - Addiction, 1996 - Wiley Online Library
Cannabis is one of the most widely used drugs throughout the world. The psychoactive
constituent of cannabis, δ9‐tetrahydrocannabinol (δ9‐THC), produces a myriad of …

Cannabinoid physiology and pharmacology: 30 years of progress

AC Howlett, CS Breivogel, SR Childers… - …, 2004 - Elsevier
Δ9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528 …

Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability

V Chevaleyre, PE Castillo - Neuron, 2003 - cell.com
Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically
dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy …

Cannabinoid receptor signaling

AC Howlett - Cannabinoids, 2005 - Springer
The cannabinoid receptor family currently includes twotypes: CB 1, characterized in
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase

B Kola, E Hubina, SA Tucci, TC Kirkham… - Journal of Biological …, 2005 - ASBMB
Endocannabinoids and ghrelin are potent appetite stimulators and are known to interact at a
hypothalamic level. However, both also have important peripheral actions, including …

Neuropsychological functioning in adolescent marijuana users: subtle deficits detectable after a month of abstinence

KL Medina, KL Hanson, AD Schweinsburg… - Journal of the …, 2007 - cambridge.org
In adults, studies examining the long-lasting cognitive effects of marijuana use demonstrate
subtle deficits in attention, executive function, and memory. Because neuromaturation …

Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system

JM McPartland, GW Guy, V Di Marzo - PloS one, 2014 - journals.plos.org
Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …

Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress

MN Hill, S Patel, EJ Carrier, DJ Rademacher… - …, 2005 - nature.com
Deficits in cognitive functioning and flexibility are seen following both chronic stress and
modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether …

Blunted psychotomimetic and amnestic effects of Δ-9-tetrahydrocannabinol in frequent users of cannabis

DC D'souza, M Ranganathan, G Braley… - …, 2008 - nature.com
Cannabis is one of the most widely used illicit substances and there is growing interest in
the association between cannabis use and psychosis. Delta-9-Tetrahydrocannabinol (Δ-9 …