The use of multigene panels for the assessment of cancer susceptibility is expanding rapidly
in clinical practice, particularly in the USA, despite concerns regarding the uncertain clinical …

Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …

Importance Hereditary factors play a key role in the risk of developing several cancers.
Identification of a germline predisposition can have important implications for treatment …

PURPOSE Genetic testing for cancer risk has expanded rapidly. We examined clinical
genetic testing and results among population-based patients with breast and ovarian …

Purpose Testing for germline mutations in BRCA1/2 is standard for select patients with
breast cancer to guide clinical management. Next-generation sequencing (NGS) allows …

BACKGROUND As panel testing becomes more common in clinical practice, it is important
to understand the prevalence and trends associated with the pathogenic variants (PVs) …

Purpose Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes
MLH1, MSH2, and MSH6 is predominantly associated with colorectal and endometrial …

Purpose Genetic testing for breast cancer risk is evolving rapidly, with growing use of
multiple-gene panels that can yield uncertain results. However, little is known about the …

PURPOSE Genetic testing is important for breast and ovarian cancer risk reduction and
treatment, yet little is known about its evolving use. METHODS SEER records of women of …

Purpose: The prevalence of mutations in cancer susceptibility genes such as BRCA1 and
BRCA2 and other cancer susceptibility genes and their clinical relevance are largely …