Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

The active electrical properties of dendrites shape neuronal input and output and are
fundamental to brain function. However, our knowledge of active dendrites has been almost …

Pyramidal neurons represent the majority of excitatory neurons in the neocortex. Each
pyramidal neuron receives input from thousands of excitatory synapses that are segregated …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

▪ Abstract The highly interconnected networks of the mammalian forebrain can generate a
wide variety of synchronized activities, including those underlying epileptic seizures, which …

The pyramidal neuron is the principal cell type in the mammalian forebrain, but its function
remains poorly understood. Using a detailed compartmental model of a hippocampal CA1 …

Synaptic plasticity serves as a cellular substrate for information storage in the central
nervous system. The entorhinal cortex (EC) and hippocampus are interconnected brain …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …