The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

Cellular hypoxia is the common final pathway of brain injury that occurs not just after
asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or …

Barometric pressure falls with increasing altitude and consequently there is a reduction in
the partial pressure of oxygen resulting in a hypoxic challenge to any individual ascending …

We conducted a systematic review and meta-regression analysis to quantify effects of
exercise on brain hemodynamics measured by near-infrared spectroscopy (NIRS). The …

Blood flow (BF) increases with increasing exercise intensity in skeletal, respiratory, and
cardiac muscle. In humans during maximal exercise intensities, 85% to 90% of total cardiac …

Constant cerebral blood flow (CBF) is vital to human survival. Originally thought to receive
steady blood flow, the brain has shown to experience increases in blood flow during …

During exercise: the Kety-Schmidt-determined cerebral blood flow (CBF) does not change
because the jugular vein is collapsed in the upright position. In contrast, when CBF is …

Objective: Some patients with postconcussion syndrome (PCS) have reduced exercise
capacity that may reflect altered central cardiorespiratory control. The purpose of this study …