SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

AD Proal, MB VanElzakker, S Aleman, K Bach… - Nature …, 2023 - nature.com
Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

How COVID-19 shaped mental health: from infection to pandemic effects

BWJH Penninx, ME Benros, RS Klein, CH Vinkers - Nature medicine, 2022 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has threatened global
mental health, both indirectly via disruptive societal changes and directly via …

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

SR Stein, SC Ramelli, A Grazioli, JY Chung, M Singh… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction,–
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] The neurobiology of long COVID

M Monje, A Iwasaki - Neuron, 2022 - cell.com
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of
people after COVID-19 and represent a major component of the post-acute COVID-19 …

Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

ZA Sherif, CR Gomez, TJ Connors, TJ Henrich… - Elife, 2023 - elifesciences.org
COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional
malaise, and cognitive dysfunction that last for months and impact everyday functioning, is …

Viral persistence, reactivation, and mechanisms of long COVID

B Chen, B Julg, S Mohandas, SB Bradfute - Elife, 2023 - elifesciences.org
The COVID-19 global pandemic caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection has infected hundreds of millions of individuals …

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - Nature, 2022 - nature.com
There is strong evidence of brain-related abnormalities in COVID-19,,,,,,,,,,,–. However, it
remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder …

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

M Khan, SJ Yoo, M Clijsters, W Backaert, A Vanstapel… - Cell, 2021 - cell.com
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure …

[HTML][HTML] Dysregulation of brain and choroid plexus cell types in severe COVID-19

AC Yang, F Kern, PM Losada, MR Agam, CA Maat… - Nature, 2021 - nature.com
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …

[HTML][HTML] Long COVID or post-acute sequelae of COVID-19 (PASC): an overview of biological factors that may contribute to persistent symptoms

AD Proal, MB VanElzakker - Frontiers in microbiology, 2021 - frontiersin.org
The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused
a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients …