The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Within the past 10 years the field of signaling via extracellular nucleotides has witnessed a
breath-taking expansion. Molecular cloning of receptors and physiological and …

Skeletal muscles contain resident immune cell populations and their abundance and type is
altered in inflammatory myopathies, endotoxemia or different types of muscle injury/insult …

Muscular dystrophies represent a heterogeneous group of disorders, which have been
largely classified by clinical phenotype. In the last 10 years, identification of novel skeletal …

Mutations of different components of the dystrophin–glycoprotein complex (DGC) cause
muscular dystrophies that vary in terms of severity, age of onset, and selective involvement …

The dystrophin–glycoprotein complex (DGC) is a multisubunit complex that connects the
cytoskeleton of a muscle fiber to its surrounding extracellular matrix. Mutations in the DGC …

Dystrophin is a 427 kDa sub-membrane cytoskeletal protein, associated with the inner
surface membrane and incorporated in a large macromolecular complex of proteins, the …

The molecular events by which eccentric muscle contractions induce muscle damage and
remodelling remain largely unknown. We assessed whether eccentric exercise modulates …

ATP, besides an intracellular energy source, is an agonist when applied to a variety of
different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are …