Infrared multiphoton dissociation spectroscopy with free‐electron lasers: On the road from small molecules to biomolecules

L Jašíková, J Roithová - Chemistry–A European Journal, 2018 - Wiley Online Library
Infrared multiphoton dissociation (IRMPD) spectroscopy is commonly used to determine the
structure of isolated, mass‐selected ions in the gas phase. This method has been widely …

Gas-phase conformations and N-glycosidic bond stabilities of sodium cationized 2′-deoxyguanosine and guanosine: sodium cations preferentially bind to the …

Y Zhu, LA Hamlow, CC He, JK Lee, J Gao… - The Journal of …, 2017 - ACS Publications
2′-Deoxyguanosine (dGuo) and guanosine (Guo) are fundamental building blocks of DNA
and RNA nucleic acids. In order to understand the effects of sodium cationization on the gas …

Structural characterization of nucleotide 5′-triphosphates by infrared ion spectroscopy and theoretical studies

RE Van Outersterp, J Martens, G Berden… - Physical Chemistry …, 2018 - pubs.rsc.org
The molecular family of nucleotide triphosphates (NTPs), with adenosine 5′-triphosphate
(ATP) as its best-known member, is of high biochemical importance as their phosphodiester …

Influence of sodium cationization versus protonation on the gas-phase conformations and glycosidic bond stabilities of 2′-deoxyadenosine and adenosine

Y Zhu, LA Hamlow, CC He, SF Strobehn… - The Journal of …, 2016 - ACS Publications
The influence of noncovalent interactions with a sodium cation on the gas-phase structures
and N-glycosidic bond stabilities of 2′-deoxyadenosine (dAdo) and adenosine …

IRMPD action spectroscopy, ER-CID experiments, and theoretical studies of sodium cationized thymidine and 5-methyluridine: kinetic trapping during the ESI …

Y Zhu, HA Roy, NA Cunningham… - Journal of The …, 2017 - ACS Publications
Thymidine (dThd) is a fundamental building block of DNA nucleic acids, whereas 5-
methyluridine (Thd) is a common modified nucleoside found in tRNA. In order to determine …

Effects of sodium cationization versus protonation on the conformations and N-glycosidic bond stabilities of sodium cationized Urd and dUrd: solution conformation of …

Y Zhu, HA Roy, NA Cunningham… - Physical Chemistry …, 2017 - pubs.rsc.org
Uridine (Urd) is one of the naturally occurring pyrimidine nucleosides of RNA. 2′-
Deoxyuridine (dUrd) is a naturally occurring modified form of Urd, but is not one of the …

Structural and energetic effects of O2′-ribose methylation of protonated purine nucleosides

CC He, LA Hamlow, ZJ Devereaux, Y Zhu… - The Journal of …, 2018 - ACS Publications
The chemical difference between DNA and RNA nucleosides is their 2′-hydrogen versus
2′-hydroxyl substituents. Modification of the ribosyl moiety at the 2′-position and 2′-O …

Structural determination of arginine-linked cisplatin complexes via IRMPD action spectroscopy: arginine binds to platinum via NO− binding mode

CC He, LA Hamlow, B Kimutai, HA Roy… - Physical Chemistry …, 2021 - pubs.rsc.org
Cisplatin,(NH3) 2PtCl2, has been known as a successful metal-based anticancer drug for
more than half a century. Its analogue, Argplatin, arginine-linked cisplatin,(Arg) PtCl2, is …

Conformations and N-glycosidic bond stabilities of sodium cationized 2′-deoxycytidine and cytidine: solution conformation of [Cyd+ Na]+ is preserved upon ESI

Y Zhu, LA Hamlow, CC He, HA Roy… - International Journal of …, 2018 - Elsevier
The local structures of DNA and RNA are influenced by protonation, deprotonation and
noncovalent interactions with metal cations. In order to determine the effects of sodium …

N3 and O2 protonated conformers of the cytosine mononucleotides coexist in the gas phase

RR Wu, LA Hamlow, CC He, Y Nei… - Journal of the …, 2017 - ACS Publications
The gas-phase conformations of the protonated forms of the DNA and RNA cytosine
mononucleotides,[pdCyd+ H]+ and [pCyd+ H]+, are examined by infrared multiple photon …