Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Drug delivery is the method or process of administering a pharmaceutical compound to
achieve a therapeutic effect in humans or animals. For the treatment of human diseases …

Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting
approach for poorly soluble drugs. Nanocrystals provide special features including …

One of the major problems associated with poorly soluble drugs is very low bioavailability.
The problem is even more complex for drugs like itraconazole, simvastatin, and …

Poor solubility of new drugs and their related low oral bioavailability and general delivery
problems are becoming a major challenge. Nanocrystals being a kind of “universal” …

" Completely revised and expanded throughout. Presents a comprehensive integrated,
sequenced approach to drug dosage formulation, design, and evaluation. Indentifies the …

A surprisingly large proportion of new drug candidates emerging from drug discovery
programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned …

An increasing number of newly developed drugs are poorly soluble; in many cases drugs
are poorly soluble in both aqueous and organic media excluding the traditional approaches …

Rapid advancement in drug discovery process is leading to a number of potential new drug
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …

Nanosizing is one of the most important drug delivery platform approaches for the
commercial development of poorly soluble drug molecules. The research efforts of many …