Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …

Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be
therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays …

Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of
nucleotides in cell proliferation, thus impaired purine metabolism is associated with the …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

Background & Aims Gut microbial dysbiosis has pivotal involvement in colorectal cancer
(CRC). However, the intratumoral microbiota and its association with CRC progression …

Background & Aims Mutant KRAS promotes glutaminolysis, a process that uses steps from
the tricarboxylic cycle to convert glutamine to α-ketoglutarate and other molecules via …

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC
count may not be the “best” indicator of metastatic risk because their heterogeneity is …

Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …