Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Interactions among β-sheets occur widely in protein quaternary structure, protein–protein
interaction, and protein aggregation and are central in Alzheimer's and other amyloid …

The amyloid protein aggregation associated with diseases such as Alzheimer's, Parkinson's
and type II diabetes (among many others) features a bewildering variety of β-sheet-rich …

What I cannot create, I do not understand. Richard P. Feynman β-Sheets consist of
extended polypeptide strands (β-strands) connected by a network of hydrogen bonds and …

The simplest peptide structural element is the peptide β-strand. The β-strand is a linear or
sawtoothed arrangement of amino acids with amide bonds being almost coplanar, side …

A modular strategy to artificial double helices A modular strategy to artificial double helices
Angew Chem Int Ed Engl. 2005 Jun 20;44(25):3867-70. doi: 10.1002/anie.200501028 …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Metal complexes with open coordination sites have found wide use in molecular recognition.
They serve as binding sites in the development of chemosensors, 1 to study metalloenzyme …

Different classes of foldamers, which are synthetic oligomers that adopt well-defined
conformations in solution, have been the subject of extensive studies devoted to the …