The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated
with proteasomes and exerts a dual function in regulating protein degradation. USP14 …

Targeted protein degradation allows targeting undruggable proteins for therapeutic
applications as well as eliminating proteins of interest for research purposes. While several …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Proteasomal deubiquitinase (DUB) inhibition has been found to be effective in experimental
cancer therapy by inducing proteasome inhibition and apoptosis. Ferroptosis is a form of …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Platinum drugs are extensively used in the clinic to treat cancer, often leading to a palliative
response rather than a cure. While DNA is considered to be the primary target of platinum …

In the past 15 years, the proteasome has been validated as an anti-cancer drug target and
20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the …

Gold nanoparticles (AuNPs) are widely used in biomedicine due to their remarkable
therapeutic applications. However, little is known about their cytotoxic effects on the ubiquitin …

Cancer stem cells (CSCs) exhibit highly aggressive and metastatic features and resistance
to chemotherapy and radiotherapy. Aryl hydrocarbon receptor (AhR) expression varies …