Investigations into the mixed muscle–secretory phenotype of cardiomyocytes from the atrial
appendages of the heart led to the discovery that these cells produce, in a regulated …

The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

Abstract Moorman, Antoon FM, and Vincent M. Christoffels. Cardiac Chamber Formation:
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …

In this review, we focus on two important steps in the formation of the embryonic heart:(i) the
progressive addition of late differentiating progenitor cells from the second heart field that …

In 2014, an extensive review discussing the major steps of cardiac development focusing on
growth, formation of primary and chamber myocardium and the development of the cardiac …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

During development, progenitors progress through transition states. The cardiac epicardium
contains progenitors of essential non-cardiomyocytes. The Hippo pathway, a kinase …

During heart development the second heart field (SHF) provides progenitor cells for most
cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that …

Cardiac cushion development provides a valuable system to investigate epithelial to
mesenchymal transition (EMT), a fundamental process in development and tumor …