Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Background Cannabidiol (CBD) is one of the major constituents of Cannabis sativa L. that
lacks psychotomimetic and rewarding properties and inhibits the rewarding and reinforcing …

Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …

The dopamine (DA) hypothesis posits the increase of mesolimbic dopamine levels as a
defining commonality of addictive drugs, initially causing reinforcement, eventually leading …

Highlights•NAcore astrocytes undergo morphological remodeling after addictive drug use
resulting in their reduced synaptic proximity.•Repeated self-administration of …

Clinical studies suggest that women are more likely than men to relapse to alcohol drinking
in response to stress; however, the mechanisms underlying this sex difference are not well …

Individuals with mood disorders or with addiction, impulsivity and some personality
disorders can share in common a dysfunction in how the brain perceives reward, where …

Addiction poses significant social, health, and criminal issues. Its moderate heritability and
early-life impact, affecting reproductive success, poses an evolutionary paradox: why are …

One of the main obstacles in treating psychostimulant addiction is relapse even after long-
term abstinence. The nucleus accumbens (NAc) is located in the basal forebrain …

An animal model of voluntary oral morphine consumption would allow for a pre-clinical
evaluation of new treatments aimed at reducing opioid intake in humans. However, the main …