Biological roles of glycans

A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

The type II secretion system: biogenesis, molecular architecture and mechanism

KV Korotkov, M Sandkvist, WGJ Hol - Nature Reviews Microbiology, 2012 - nature.com
Many Gram-negative bacteria use the sophisticated type II secretion system (T2SS) to
translocate a wide range of proteins from the periplasm across the outer membrane. The …

Carbohydrate-binding domains: multiplicity of biological roles

D Guillén, S Sánchez, R Rodríguez-Sanoja - Applied microbiology and …, 2010 - Springer
Insoluble polysaccharides can be degraded by a set of hydrolytic enzymes formed by
catalytic modules appended to one or more non-catalytic carbohydrate-binding modules …

Sialidases from gut bacteria: a mini-review

N Juge, L Tailford, CD Owen - Biochemical Society Transactions, 2016 - portlandpress.com
Sialidases are a large group of enzymes, the majority of which catalyses the cleavage of
terminal sialic acids from complex carbohydrates on glycoproteins or glycolipids. In the …

Metagenomic characterization of the enhanced performance of anaerobic fermentation of waste activated sludge with CaO2 addition at ambient temperature: fatty acid …

Q Ping, M Zheng, X Dai, Y Li - Water research, 2020 - Elsevier
This study investigated the chemical and genetic mechanisms of anaerobic fermentation of
waste activated sludge (WAS) with CaO 2 addition at ambient temperature. The microbial …

Host sialoglycans and bacterial sialidases: a mucosal perspective

AL Lewis, WG Lewis - Cellular microbiology, 2012 - Wiley Online Library
Sialic acids are nine‐carbon‐backbone sugars that occupy outermost positions on
vertebrate cells and secreted sialoglycoproteins. These negatively charged hydrophilic …

Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model

A Buisson, H Sokol, N Hammoudi, X Treton, M Nachury… - Gut, 2023 - gut.bmj.com
Objective We used the postoperative recurrence model to better understand the role of
adherent and invasive Escherichia coli (AIEC) bacteria in Crohn's disease (CD), taking …

Computational screening and MM/GBSA-based MD simulation studies reveal the high binding potential of FDA-approved drugs against Cutibacterium acnes …

AP Singh, S Ahmad, K Raza… - Journal of Biomolecular …, 2024 - Taylor & Francis
Cutibacterium acnes is an opportunistic pathogen linked with acne vulgaris, affecting 80–
90% of teenagers globally. On the leukocyte (WBCs) cell surface, the cell wall anchored …

Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production

G Soong, A Muir, MI Gomez, J Waks… - The Journal of …, 2006 - Am Soc Clin Investig
Many respiratory pathogens, including Hemophilus influenzae, Streptococcus pneumoniae,
and Pseudomonas aeruginosa, express neuraminidases that can cleave α2, 3-linked sialic …

The NanA Neuraminidase of Streptococcus pneumoniae Is Involved in Biofilm Formation

D Parker, G Soong, P Planet, J Brower… - Infection and …, 2009 - Am Soc Microbiol
Streptococcus pneumoniae remains a major cause of bacteremia, pneumonia, and otitis
media despite vaccines and effective antibiotics. The neuraminidase of S. pneumoniae …