Photocatalytic late-stage C–H functionalization
The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …
significantly spurred innovative late-stage C–H functionalization approaches that make use …
Toolbox for distal C–H bond functionalizations in organic molecules
Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
Nitrogen-Centered Radicals in Functionalization of sp2 Systems: Generation, Reactivity, and Applications in Synthesis
C Pratley, S Fenner, JA Murphy - Chemical reviews, 2022 - ACS Publications
The chemistry of nitrogen-centered radicals (NCRs) has plentiful applications in organic
synthesis, and they continue to expand as our understanding of these reactive species …
synthesis, and they continue to expand as our understanding of these reactive species …
Late-stage C–H functionalization offers new opportunities in drug discovery
L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
Photocatalysis in the life science industry
L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …
industry require access to mild and robust synthetic methodologies to systematically modify …
Strategies to generate nitrogen-centered radicals that may rely on photoredox catalysis: development in reaction methodology and applications in organic synthesis
For more than 70 years, nitrogen-centered radicals have been recognized as potent
synthetic intermediates. This review is a survey designed for use by chemists engaged in …
synthetic intermediates. This review is a survey designed for use by chemists engaged in …
[HTML][HTML] Recent advances in visible light-activated radical coupling reactions triggered by (i) ruthenium,(ii) iridium and (iii) organic photoredox agents
Photoredox chemistry with organic or transition metal agents has been reviewed in earlier
years, but such is the pace of progress that we will overlap very little with earlier …
years, but such is the pace of progress that we will overlap very little with earlier …
Photoredox-catalyzed C–H functionalization reactions
N Holmberg-Douglas, DA Nicewicz - Chemical reviews, 2021 - ACS Publications
The fields of C–H functionalization and photoredox catalysis have garnered enormous
interest and utility in the past several decades. Many different scientific disciplines have …
interest and utility in the past several decades. Many different scientific disciplines have …
Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds
R Cannalire, S Pelliccia, L Sancineto… - Chemical Society …, 2021 - pubs.rsc.org
The late stage functionalization (LSF) of complex biorelevant compounds is a powerful tool
to speed up the identification of structure–activity relationships (SARs) and to optimize …
to speed up the identification of structure–activity relationships (SARs) and to optimize …
Switchable divergent synthesis using photocatalysis
Y Sakakibara, K Murakami - ACS Catalysis, 2022 - ACS Publications
A highly selective and divergent synthesis enables access to various molecules and has
garnered broad interest from not only organic chemists but also medicinal chemists and …
garnered broad interest from not only organic chemists but also medicinal chemists and …