Living on the edge of the CNS: meninges cell diversity in health and disease

J Derk, HE Jones, C Como, B Pawlikowski… - Frontiers in cellular …, 2021 - frontiersin.org
The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …

Neurovascular communication during CNS development

I Paredes, P Himmels, CR de Almodovar - Developmental cell, 2018 - cell.com
A precise communication between the nervous and the vascular systems is crucial for
proper formation and function of the central nervous system (CNS). Interestingly, this …

A single-cell atlas of the normal and malformed human brain vasculature

EA Winkler, CN Kim, JM Ross, JH Garcia, E Gil, I Oh… - Science, 2022 - science.org
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

Blood vessel formation in cerebral organoids formed from human embryonic stem cells

O Ham, YB Jin, J Kim, MO Lee - Biochemical and Biophysical Research …, 2020 - Elsevier
Current cerebral organoid technology provides excellent in vitro models mimicking the
structure and function of the developing human brain, which enables studies on normal and …

Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer's disease

Q Yue, MPM Hoi - Neural Regeneration Research, 2023 - journals.lww.com
Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Developmental biology of the meninges

K Dasgupta, J Jeong - Genesis, 2019 - Wiley Online Library
The meninges are membranous layers surrounding the central nervous system. In the head,
the meninges lie between the brain and the skull, and interact closely with both during …

[HTML][HTML] Advancing human induced pluripotent stem cell‐derived blood‐brain barrier models for studying immune cell interactions

H Nishihara, BD Gastfriend, S Soldati, S Perriot… - The FASEB …, 2020 - ncbi.nlm.nih.gov
Human induced pluripotent stem cell (hiPSC)‐derived blood‐brain barrier (BBB) models
established to date lack expression of key adhesion molecules involved in immune cell …

[HTML][HTML] Neurovascular crosstalk coordinates the central nervous system development

B Peguera, M Segarra, A Acker-Palmer - Current opinion in neurobiology, 2021 - Elsevier
Purpose of the review: The synchronic development of vascular and nervous systems is
orchestrated by common molecules that regulate the communication between both systems …

Signaling pathways in neurovascular development

A Rattner, Y Wang, J Nathans - Annual review of neuroscience, 2022 - annualreviews.org
During development, the central nervous system (CNS) vasculature grows to precisely meet
the metabolic demands of neurons and glia. In addition, the vast majority of the CNS …

Blood‐brain barrier development: systems modeling and predictive toxicology

KS Saili, TJ Zurlinden, AJ Schwab, A Silvin… - Birth defects …, 2017 - Wiley Online Library
The blood‐brain barrier (BBB) serves as a gateway for passage of drugs, chemicals,
nutrients, metabolites, and hormones between vascular and neural compartments in the …