Cardiovascular diseases remain a large global health problem. Although several
conventional small-molecule treatments are available for common cardiovascular problems …

The age-adjusted prevalence of peripheral arterial disease in the US population has been
estimated to approach 12%. The clinical consequences of occlusive peripheral arterial …

Cardiovascular diseases (CVDs) are the leading cause of death and disability in Europe,
posing a great social and economic burden. Coronary artery disease (CAD) is the cause of …

Chronic cardiovascular diseases are significant health problems. Although current treatment
strategies have tremendously improved disease management, up to 30% of these patients …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Despite significant advances in medical, interventional, and surgical therapy for coronary
and peripheral arterial disease, the burden of these illnesses remains high. To address this …

Based on the increasingly understood regenerative capacity of the human heart and
vascular system, 1 cardiovascular regenerative medicine (CRM) encompasses all potential …

Rationale: Ischemic cardiovascular disease represents one of the largest epidemics
currently facing the aging population. Current literature has illustrated the efficacy of …

Objective—In response to tissue injury, the appropriate progression of events in
angiogenesis is controlled by a careful balance between pro and antiangiogenic factors. We …

Since the discovery of vascular endothelial growth factor (VEGF), therapeutic angiogenesis
has attracted interest as an alternative treatment for ischaemic heart and peripheral disease …