Plant genomes encode various small RNAs that function in distinct, yet overlapping, genetic
and epigenetic silencing pathways. However, the abundance and diversity of small-RNA …

Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to
conveying the epigenetic program, it is still unclear how a defined chromatin domain is …

Small RNA molecules of about 20–30 nucleotides have emerged as powerful regulators of
gene expression and genome stability. Studies in fission yeast and multicellular organisms …

Nuclear transcription is not restricted to genes but occurs throughout the intergenic and
noncoding space of eukaryotic genomes. The functional significance of this widespread …

The finding that sequence-specific gene silencing occurs in response to the presence of
double-stranded RNAs has had an enormous impact on biology, uncovering an …

Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate
sequence-specific regulation of diverse biological processes. Here, we combine deep …

The involvement of RNA interference (RNAi) in heterochromatin formation has become clear
largely through studies in the fission yeast Schizosaccharomyces pombe and plants like …