Hemocompatibility challenge of membrane oxygenator for artificial lung technology

BPN Thi, BTD Nguyen, IS Jeong, JF Kim - Acta Biomaterialia, 2022 - Elsevier
The artificial lung (AL) technology is one of the membrane-based artificial organs that partly
augments lung functions, ie blood oxygenation and CO 2 removal. It is generally employed …

Commercial and novel anticoagulant ECMO coatings: a review

C Zhao, K Sheng, T Bao, T Shi, P Liu, Y Yan… - Journal of Materials …, 2023 - pubs.rsc.org
Extracorporeal membrane oxygenation (ECMO) is an invasive and last-resort treatment for
circulatory and respiratory failure. Prolonged ECMO support can disrupt the coagulation and …

[HTML][HTML] Superamphiphobic blood-repellent surface modification of porous fluoropolymer membranes for blood oxygenation applications

E Yi, HS Kang, SM Lim, HJ Heo, D Han, JF Kim… - Journal of Membrane …, 2022 - Elsevier
Biomedical gas exchange membranes used for blood oxygenation, including extracorporeal
membrane oxygenators (ECMO) and artificial lung technology, have suffered from the …

Mechanisms for Reduced Fibrin Clot Formation on Liquid‐Infused Surfaces

JK Hong, AM Ruhoff, K Mathur, C Neto… - Advanced …, 2022 - Wiley Online Library
Biomedical devices are prone to blood clot formation (thrombosis), and liquid‐infused
surfaces (LIS) are effective in reducing the thrombotic response. However, the mechanisms …

Development and Blood Compatibility of a Stable and Bioactive Metal–Organic Framework Composite Coating for Blood-Circulation Tubing

AC Melvin, TV Wick, Y Zang, GT Harea… - ACS Biomaterials …, 2022 - ACS Publications
Medical devices that require substantial contact between blood and a foreign surface would
be dramatically safer if constructed from materials that prevent clot formation and …

Enhanced Anticoagulation of Hierarchy Liquid Infused Surfaces in Blood Flow

S Zhang, Y Wang, K Meng, X Zheng, Y Li… - ACS Applied Materials …, 2023 - ACS Publications
Liquid infused surfaces (LIS) hold remarkable potential in anticoagulation. However, liquid
loss of LIS in the bloodstream remains a challenge toward its clinical application. Here …

Extracorporeal life support without systemic anticoagulation: a nitric oxide-based non-thrombogenic circuit for the artificial placenta in an ovine model

BP Fallon, O Lautner-Csorba, TC Major, G Lautner… - Pediatric …, 2024 - nature.com
Background Clinical translation of the extracorporeal artificial placenta (AP) is impeded by
the high risk for intracranial hemorrhage in extremely premature newborns. The Nitric Oxide …

Design Optimization of Perfluorinated Liquid‐Infused Surfaces for Blood‐Contacting Applications

JK Hong, K Mathur, AM Ruhoff… - Advanced Materials …, 2022 - Wiley Online Library
Tethered‐liquid perfluorocarbon (TLP) coatings show promise for blood‐contacting medical
device applications to reduce blood adhesion and delay thrombosis. However, their …

Robust, Scalable Microfluidic Manufacturing of RNA–Lipid Nanoparticles Using Immobilized Antifouling Lubricant Coating

YH Hwang, SJ Shepherd, D Kim, AJ Mukalel… - ACS …, 2024 - ACS Publications
Despite the numerous advantages demonstrated by microfluidic mixing for RNA-loaded lipid
nanoparticle (RNA-LNP) production over bulk methods, such as precise size control …

Perfluorocarbons in research and clinical practice: a narrative review

G Nocentini, G MacLaren, R Bartlett, D De Luca… - Asaio …, 2023 - journals.lww.com
Perfluorocarbons (PFCs) are organic liquids derived from hydrocarbons in which some of
the hydrogen atoms have been replaced by fluorine atoms. They are chemically and …