The postsynaptic density (PSD) of excitatory synapses is built from a wide variety of
scaffolding proteins, receptors, and signaling molecules that collectively orchestrate synaptic …

De novo heterozygous mutations in activity-dependent neuroprotective protein (ADNP)
cause autistic ADNP syndrome. ADNP mutations impair microtubule (MT) function, essential …

Shank3 is a member of the Shank family proteins (Shank1–3), which are abundantly present
in the postsynaptic density (PSD) of neuronal excitatory synapses. As a core scaffold in the …

The widespread presence of mercury, a heavy metal found in the environment and used in
numerous industries and domestic, raises concerns about its potential impact on human …

Postsynaptic scaffold proteins such as Shank, PSD-95, Homer and SAPAP/GKAP family
members establish the postsynaptic density of glutamatergic synapses through a dense …

Phelan-McDermid syndrome (PMDS) arises from mutations in the terminal region of
chromosome 22q13, impacting the SHANK3 gene. The resulting deficiency of the …

Shank proteins are major scaffolds of the postsynaptic density of excitatory synapses.
Mutations in SHANK genes are associated with autism and intellectual disability. The effects …

Background Pancreatic cancer is a highly aggressive and lethal disease with limited
treatment options. In this study, we investigated the potential therapeutic effects of …

Autism spectrum disorders represent a diverse etiological spectrum that converge on a
syndrome characterized by discrepant deficits in developmental domains often highlighted …

Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction, and repetitive …