Living organisms have evolved a plethora of sensing systems for the intra-and extracellular
detection of small molecules, ions or physical parameters. Several recent studies have …

Population heterogeneity is omnipresent in all bioprocesses even in homogenous
environments. Its origin, however, is only so well understood that potential strategies like bet …

Successful scale-up of bioprocesses requires that laboratory-scale performance is equally
achieved during large-scale production to meet economic constraints. In industry, heuristic …

Metaproteomics—the large‐scale characterization of the entire protein complement of
environmental microbiota at a given point in time—has provided new features to study …

Highlights•A new generation of mass analyzers is dramatically changing proteomics
throughput.•Proteogenomics consists of the combination of genomic, transcriptomic, and …

Phenotypic heterogeneity within microbial populations arises even when the cells are
exposed to putatively constant and homogeneous conditions. The outcome of this …

Since high-value bacterial secondary metabolites, including antibiotics, are often naturally
produced in only low amounts, their efficient biosynthesis typically requires the transfer of …

Phenotypic diversification is key to microbial adaptation. Currently, advanced technological
approaches offer insights into cell-to-cell variation of bacterial populations at a …

Typically, bioprocesses on an industrial scale are dynamic systems with a certain degree of
variability, system inhomogeneities, and even population heterogeneities. Therefore, the …

Highlights•Clonal cultures employ strategies for diversification to encounter constraints.•Cell
division is a major source of phenotypic variation due to unequal partitioning of cellular …