In several neurodegenerative diseases that are collectively called tauopathies, progressive
accumulation of tau in the brain is closely associated with neurodegeneration and cognitive …

Ironically, population aging which is considered a public health success has been
accompanied by a myriad of new health challenges, which include neurodegenerative …

Background Amyloid positron emission tomography (PET) has become an important tool to
identify amyloid-β (Aβ) pathology in Alzheimer's disease (AD) patients. Here, we determined …

Abstract β-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN)
are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks …

The dynamics of β-amyloid deposition and related second-order physiological effects, such
as regional cerebral blood flow (rCBF), are key factors for a deeper understanding of …

Purpose Characteristic features of amyloid-PET (A), tau-PET (T), and FDG-PET (N) can
serve for the A/T/N classification of neurodegenerative diseases. Recent studies showed …

Purpose Drugs promoting myelin repair represent a promising therapeutic approach in
multiple sclerosis and several candidate molecules are currently being evaluated, fostering …

Alzheimer's disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder.
As the exact cause of the disease is still unclear, the drug development is very challenging …

It has been estimated that every year, millions of people are affected by neurodegenerative
disorders, which complicate their lives and their caregivers' lives. To date, there has not …

The progression of β-amyloid deposition in the brains of mice overexpressing Swedish
mutant β-amyloid precursor protein (APP-Swe), a model of Alzheimer disease (AD), was …