Cognitive impairment is a core feature of schizophrenia, which is predictive for functional
outcomes and is, therefore, a treatment target in itself. Yet, literature on efficacy of different …

The negative symptoms of schizophrenia represent an impairment of normal emotional
responses, thought processes and behaviors, and include blunting or flattening of affect …

BACKGROUND: Primary negative symptoms of schizophrenia (NSS) contribute heavily to
functional disability and treatment of these symptoms continues to be a major unmet need …

Modafinil is a central nervous system wake promoting agent used for the treatment of
excessive daytime sleeping. Its vigilance promoting properties and low abuse potential has …

Social cognition is a major problem underlying deficiencies in interpersonal relationships in
several psychiatric populations. And yet there is currently no gold standard for …

Modafinil is a nonamphetamine nootropic drug with an increasingly therapeutic interest due
to its different sites of action and behavioral effects in comparison to cocaine or …

Preparations of plasma‐derived small extracellular vesicles (sEVs) were deployed as liquid
biopsy to study cytochrome P450 (CYP) 3A4 (CYP3A4) induction following modafinil 400 mg …

Rationale Current treatments for schizophrenia have modest, if any, efficacy on cognitive
dysfunction, creating a need for novel therapies. Their development requires predictive …

Introduction: Fibromyalgia (FM) is a common, complex chronic widespread pain condition is
characterized by fatigue, sleep disturbance and cognitive dysfunction. Treatment of FM is …

Introduction: Fibromyalgia (FM) is a chronic disorder whose symptoms of pain, fatigue, sleep
disturbances and depression have a devastating effect on patients' lives as it limits their …