Traditionally, vaccines have helped eradication of several infectious diseases and also
saved millions of lives in the human history. Those prophylactic vaccines have acted through …

Multiple myeloma is a malignant tumour of plasma cells that remains incurable for the vast
majority of patients, with a median survival of 2–3 years. It is characterized by the patchy …

DNA vaccination has suddenly become a favoured strategy for inducing immunity. The
molecular precision offered by gene-based vaccines, together with the facility to include …

In the years following the publication of the initial in vivo demonstration of the ability of
plasmid DNA to generate protective immune responses, DNA vaccines have entered into a …

Cellular immune responses that protect against tumors typically have been attributed to CD8
T cells. However, CD4 T cells also play a central role. It was shown recently that, in a patient …

Due to their rapid and widespread development, DNA vaccines have entered into a variety
of human clinical trials for vaccines against various diseases including cancer. Evidence that …

Background DNA-based vaccines have been safe but weakly immunogenic in humans to
date. Methods and Findings We sought to determine the safety, tolerability, and …

Abstract mRNA vaccines for cancer immunotherapy are commonly delivered using lipid
nanoparticles (LNPs), which, when administered intravenously, may accumulate in the liver …

DNA vaccines have been widely used in efforts to develop vaccines against various
pathogens as well as for cancer, autoimmune diseases and allergy. DNA vaccines offer …

Despite recent advances in cancer therapy using vaccines, the efficacy of vaccine regimens
remains to be improved. Cutaneous transportation of biomolecules, particularly DNA …