Motor symptoms that define Parkinson's disease (PD) are caused by the selective loss of
nigral dopaminergic (DA) neurons. Cell replacement therapy for PD has been focused on …

Research on the biology of adult neural stem cells (NSCs) and induced NSCs (iNSCs), as
well as NSC-based therapies for diseases in central nervous system (CNS) has started to …

Xeroderma pigmentosum (XP) is a group of genetic disorders caused by mutations of XP-
associated genes, resulting in impairment of DNA repair. XP patients frequently exhibit …

The reprogramming of cells into induced neural stem cells (iNSCs), which are faster and
safer to generate than induced pluripotent stem cells, holds tremendous promise for …

Scientific and technological advances of the past decade have shed light on the
mechanisms underlying cell fate acquisition, including its transcriptional and epigenetic …

A characteristic of neurological disorders is the loss of critical populations of cells that the
body is unable to replace, thus there has been much interest in identifying methods of …

Alzheimer's disease (AD) is a prominent form of dementia, characterized by aggregation of
the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and …

Direct reprogramming of specialized cells into other cell types has revolutionized the fields
of stem cell, differentiation, and regenerative medicine. Direct reprogramming technology …

Great progress has been made regarding the capabilities to modify somatic cell fate ever
since the technology for generation of induced pluripotent stem cells (iPSCs) was …

Recent research has shown that defined sets of exogenous factors are sufficient to convert
rodent and human somatic cells directly into induced neural stem cells or neural precursor …