Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a
myriad of cell biological and developmental processes. Although our understanding of the …

Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

Wnts play pivotal roles during development and in the mature nervous system. However, the
mechanism by which Wnts traffic between cells has remained elusive. Here we demonstrate …

Neuromuscular junction (NMJ) formation requires agrin, a factor released from
motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin …

Localized protein synthesis requires assembly and transport of translationally silenced
ribonucleoprotein particles (RNPs), some of which are exceptionally large. Where in the cell …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

The formation of synaptic connections requires a dialogue between pre and postsynaptic
cells to coordinate the assembly of the presynaptic release machinery and the postsynaptic …

Treating neuropathic pain is a major clinical challenge, and the underlying mechanisms of
neuropathic pain remain elusive. We hypothesized that neuropathic pain–inducing nerve …

G-protein-coupled receptors (GPCRs) are cell surface receptors and are generally assumed
to signal to second messengers such as cyclic AMP (cAMP) exclusively from the plasma …

The receptor class Frizzled, which has recently been categorized as a separate group of G
protein-coupled receptors by the International Union of Basic and Clinical Pharmacology …