Antimalarial drug discovery: Progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
Manipulating the destiny of wild populations using CRISPR
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
The potential of gene drives in malaria vector species to control malaria in African environments
Gene drives are a promising means of malaria control with the potential to cause sustained
reductions in transmission. In real environments, however, their impacts will depend on local …
reductions in transmission. In real environments, however, their impacts will depend on local …
Advances and challenges in synthetic biology for mosquito control
Mosquito-borne illnesses represent a significant global health peril, resulting in
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …
Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata
A Meccariello, S Hou, S Davydova, JD Fawcett… - Nature …, 2024 - nature.com
Homing-based gene drives are recently proposed interventions promising the area-wide,
species-specific genetic control of harmful insect populations. Here we characterise a first …
species-specific genetic control of harmful insect populations. Here we characterise a first …
[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …
spread throughout a population. They could potentially be used to modify or suppress pest …
Gene drive in species complexes: Defining target organisms
JB Connolly, J Romeis, Y Devos, DCM Glandorf… - Trends in …, 2023 - cell.com
Engineered gene drives, which bias their own inheritance to increase in frequency in target
populations, are being developed to control mosquito malaria vectors. Such mosquitoes can …
populations, are being developed to control mosquito malaria vectors. Such mosquitoes can …
Metal ions in insect reproduction: a crosstalk between reproductive physiology and immunity
V Cardoso-Jaime, NA Broderick… - Current opinion in insect …, 2022 - Elsevier
Highlights•Metal ions affect reproductive physiology in hematophagous and
nonhematophagous insects.•Metal-homeostasis mechanisms may be shared between …
nonhematophagous insects.•Metal-homeostasis mechanisms may be shared between …
Burmese pythons in Florida: A synthesis of biology, impacts, and management tools
Burmese pythons (Python molurus bivittatus) are native to southeastern Asia, however, there
is an established invasive population inhabiting much of southern Florida throughout the …
is an established invasive population inhabiting much of southern Florida throughout the …
Gene drives: an alternative approach to malaria control?
K Naidoo, SV Oliver - Gene Therapy, 2024 - nature.com
Genetic modification for the control of mosquitoes is frequently touted as a solution for a
variety of vector-borne diseases. There has been some success using non-insecticidal …
variety of vector-borne diseases. There has been some success using non-insecticidal …