Antimalarial drug discovery: Progress and approaches

JL Siqueira-Neto, KJ Wicht, K Chibale… - Nature Reviews Drug …, 2023 - nature.com
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Manipulating the destiny of wild populations using CRISPR

R Raban, JM Marshall, BA Hay… - Annual review of …, 2023 - annualreviews.org
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

The potential of gene drives in malaria vector species to control malaria in African environments

PA Hancock, A North, AW Leach, P Winskill… - Nature …, 2024 - nature.com
Gene drives are a promising means of malaria control with the potential to cause sustained
reductions in transmission. In real environments, however, their impacts will depend on local …

Advances and challenges in synthetic biology for mosquito control

SC Weng, RA Masri, OS Akbari - Trends in parasitology, 2024 - cell.com
Mosquito-borne illnesses represent a significant global health peril, resulting in
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …

Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata

A Meccariello, S Hou, S Davydova, JD Fawcett… - Nature …, 2024 - nature.com
Homing-based gene drives are recently proposed interventions promising the area-wide,
species-specific genetic control of harmful insect populations. Here we characterise a first …

[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

E Yang, M Metzloff, AM Langmüller, X Xu, AG Clark… - G3, 2022 - academic.oup.com
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …

Gene drive in species complexes: Defining target organisms

JB Connolly, J Romeis, Y Devos, DCM Glandorf… - Trends in …, 2023 - cell.com
Engineered gene drives, which bias their own inheritance to increase in frequency in target
populations, are being developed to control mosquito malaria vectors. Such mosquitoes can …

Metal ions in insect reproduction: a crosstalk between reproductive physiology and immunity

V Cardoso-Jaime, NA Broderick… - Current opinion in insect …, 2022 - Elsevier
Highlights•Metal ions affect reproductive physiology in hematophagous and
nonhematophagous insects.•Metal-homeostasis mechanisms may be shared between …

Burmese pythons in Florida: A synthesis of biology, impacts, and management tools

JC Guzy, BG Falk, BJ Smith, JD Willson, RN Reed… - 2023 - digitalcommons.unl.edu
Burmese pythons (Python molurus bivittatus) are native to southeastern Asia, however, there
is an established invasive population inhabiting much of southern Florida throughout the …

Gene drives: an alternative approach to malaria control?

K Naidoo, SV Oliver - Gene Therapy, 2024 - nature.com
Genetic modification for the control of mosquitoes is frequently touted as a solution for a
variety of vector-borne diseases. There has been some success using non-insecticidal …