The alternative oxidase (AOX) is a ubiquitous terminal oxidase of plants and many fungi,
catalyzing the four‐electron reduction of oxygen to water alongside the cytochrome‐based …

In the respiratory chain of the majority of aerobic organisms, the enzyme alternative oxidase
(AOX) functions as the terminal oxidase and has important roles in maintaining metabolic …

Lipophilic bisphosphonium salts are among the most promising antiprotozoal leads currently
under investigation. As part of their preclinical evaluation we here report on their mode of …

We investigated a chemical strategy to boost the trypanocidal activity of 2, 4-
dihydroxybenzoic acid (2, 4-DHBA)-and salicylhydroxamic acid (SHAM)-based trypanocides …

In this work, efficient synthesis of isoindolin‐1‐one‐3‐phosphonates under catalyst‐and
solvent‐free conditions was reported to afford the desired compounds in excellent yields …

Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and
affordable drugs and this has necessitated this study. We investigated the trypanocidal …

We have recently reported on the development and trypanocidal activity of a class of
inhibitors of Trypanosome Alternative Oxidase (TAO) that are targeted to the mitochondrial …

In this work an efficient synthesis of isoindolin-1-one-3-phosphonates under catalyst-and
solvent-free conditions was reported to afford the desired compounds in excellent yields with …

In this work, the synthesis of isoindolin-1-one-3-phosphonates by a 'one-pot'three-
component reaction of 2-formylbenzoic acid with primary amines and dimethyl phosphite …

This chapter covers recent developments in the title area published during 2015.
Surprisingly, the past year has seen a significant decrease in the number of papers …