Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful
albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability …

Olignucleotide-based drugs show promise as a novel form of chemotherapy. Among the
hurdles that have to be overcome on the way of applicable nucleic acid therapeutics …

DNA-directed synthesis represents a powerful new tool for molecular discovery. Its ultimate
utility, however, hinges upon the diversity of chemical reactions that can be executed in the …

Oligonucleotides constitute a class of potential therapeutic agents that can be used to target
mRNA (antisense strategy), double-stranded DNA (triple-helix strategy), and even proteins …

Ever since the observation that synthetic oligonucleotides and their modified analogues can
be used successfully to modulate the functions of specific genes, 1, 2 the research on …

Abstract Tyrosyl-DNA phosphodiesterase-1 (Tdp1) is the only known enzyme to remove
tyrosine from complexes in which the amino acid is linked to the 3′-end of DNA fragments …

Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as
powerful therapeutic compounds for targeting mRNAs and inducing their degradation …

Oligonucleotide synthesis DNA oligonucleotides and DNA-RNA chimeric oligonucleotides
were prepared at IDT (Coralville, IA). RNA oligonucleotides were prepared by in vitro …

2015-08-17 Assigned to ENZO BIOCHEM, INC. reassignment ENZO BIOCHEM, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Oligomeric bioconjugates, ie oligonucleotides, peptides or oligosaccharides bearing
unnatural organic structures or constituents of other biopolymers, have during the past two …