Endoplasmic reticulum stress signalling–from basic mechanisms to clinical applications
A Almanza, A Carlesso, C Chintha… - The FEBS …, 2019 - Wiley Online Library
The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …
compartment of the secretory pathway. As such, the ER contributes to the production and …
Linking cellular stress responses to systemic homeostasis
Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …
and hence maintain microenvironmental and organismal homeostasis. Intracellular …
Evolutionary pressure against MHC class II binding cancer mutations
The anti-cancer immune response against mutated peptides of potential immunological
relevance (neoantigens) is primarily attributed to MHC-I-restricted cytotoxic CD8+ T cell …
relevance (neoantigens) is primarily attributed to MHC-I-restricted cytotoxic CD8+ T cell …
Plasticity of type I interferon-mediated responses in cancer therapy: from anti-tumor immunity to resistance
The efficacy of several therapeutic strategies against cancer, including cytotoxic drugs,
radiotherapy, targeted immunotherapies and oncolytic viruses, depend on intact type I …
radiotherapy, targeted immunotherapies and oncolytic viruses, depend on intact type I …
Endoplasmic reticulum stress in pulmonary fibrosis
A Burman, H Tanjore, TS Blackwell - Matrix Biology, 2018 - Elsevier
Endoplasmic reticulum (ER) stress is associated with development and progression of
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …
Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation
J Wu, S Chen, H Liu, Z Zhang, Z Ni, J Chen… - Journal of Experimental …, 2018 - Springer
Background Multidrug resistance remains a major obstacle to successful treatment for
patients with gastric cancer (GC). Recently, glycosylation has been demonstrated to play a …
patients with gastric cancer (GC). Recently, glycosylation has been demonstrated to play a …
[HTML][HTML] Intercellular transmission of hepatic ER stress in obesity disrupts systemic metabolism
Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated
insulin resistance. Yet, the coordinated tissue response to ERS remains unclear. Increased …
insulin resistance. Yet, the coordinated tissue response to ERS remains unclear. Increased …
A Dendritic Polymer‐Based Nanosystem Mediates Drug Penetration and Irreversible Endoplasmic Reticulum Stresses in Tumor via Neighboring Effect
X Zheng, D Pan, G Zhu, L Zhang, A Bhamra… - Advanced …, 2022 - Wiley Online Library
Nanoparticles (NPs)‐based cancer therapeutics are generally impeded by poor drug
penetration into solid tumors due to their dense tumor extracellular matrix (ECM). Herein …
penetration into solid tumors due to their dense tumor extracellular matrix (ECM). Herein …
Genetics and expression profile of the tubulin gene superfamily in breast cancer subtypes and its relation to taxane resistance
Taxanes are a class of chemotherapeutic agents that inhibit cell division by disrupting the
mitotic spindle through the stabilization of microtubules. Most breast cancer (BC) tumors …
mitotic spindle through the stabilization of microtubules. Most breast cancer (BC) tumors …
Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer
T Zhao, J Du, H Zeng - Journal of Hematology & Oncology, 2020 - Springer
To survive, cancer cells are subjected to various internal and external adverse factors,
including genetic mutations, hypoxia, nutritional deficiencies, and drug toxicity. All of these …
including genetic mutations, hypoxia, nutritional deficiencies, and drug toxicity. All of these …