[HTML][HTML] Fighting age-related orthopedic diseases: focusing on ferroptosis
Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
Extracellular vesicles in cardiovascular disease: biological functions and therapeutic implications
Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer
particles naturally released from the cell. While exosomes are formed as intraluminal …
particles naturally released from the cell. While exosomes are formed as intraluminal …
Large cardiac muscle patches engineered from human induced-pluripotent stem cell–derived cardiac cells improve recovery from myocardial infarction in swine
Background: Here, we generated human cardiac muscle patches (hCMPs) of clinically
relevant dimensions (4 cm× 2 cm× 1.25 mm) by suspending cardiomyocytes, smooth muscle …
relevant dimensions (4 cm× 2 cm× 1.25 mm) by suspending cardiomyocytes, smooth muscle …
Mitochondria-rich extracellular vesicles from autologous stem cell–derived cardiomyocytes restore energetics of ischemic myocardium
Background Mitochondrial dysfunction results in an imbalance between energy supply and
demand in a failing heart. An innovative therapy that targets the intracellular bioenergetics …
demand in a failing heart. An innovative therapy that targets the intracellular bioenergetics …
[HTML][HTML] Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing …
Human pluripotent stem cells (hPSCs)-derived cardiovascular progenitor cells (CVPCs) are
a promising source for myocardial repair, while the mechanisms remain largely unknown …
a promising source for myocardial repair, while the mechanisms remain largely unknown …
[HTML][HTML] Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction
K Lv, Q Li, L Zhang, Y Wang, Z Zhong, J Zhao, X Lin… - Theranostics, 2019 - ncbi.nlm.nih.gov
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs)
have been widely used for treating myocardial infarction (MI). However, low retention and …
have been widely used for treating myocardial infarction (MI). However, low retention and …
Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine
L Gao, L Wang, Y Wei, P Krishnamurthy… - Science translational …, 2020 - science.org
Cell therapy treatment of myocardial infarction (MI) is mediated, in part, by exosomes
secreted from transplanted cells. Thus, we compared the efficacy of treatment with a mixture …
secreted from transplanted cells. Thus, we compared the efficacy of treatment with a mixture …
Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease
The stem cell-based therapy has emerged as a promising therapeutic strategy for treating
cardiovascular ischemic diseases (CVIDs), such as myocardial infarction (MI). However …
cardiovascular ischemic diseases (CVIDs), such as myocardial infarction (MI). However …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
[HTML][HTML] Targeted delivery of extracellular vesicles in heart injury
P Chen, L Wang, X Fan, X Ning, B Yu, C Ou… - Theranostics, 2021 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are nanoscale extracellular vesicles derived from endocytosis
that are crucial to intercellular communication. EVs possess natural biocompatibility and …
that are crucial to intercellular communication. EVs possess natural biocompatibility and …