As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …

The complement system is an ancient part of innate immunity sensing highly pathogenic
coronaviruses by mannan‐binding lectin (MBL) resulting in lectin pathway activation and …

Employing a bifunctional catalyst based on a copper (I)/NHC complex and a guanidine
organocatalyst, catalytic ester reductions to alcohols with H2 as terminal reducing agent are …

Innate immune complement activation generates the C3 and C5 protein cleavage products
C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a …

G protein-coupled receptors (GPCRs) are leading druggable targets for several medicines,
but many GPCRs are still untapped for their therapeutic potential due to poor understanding …

Nonsteroidal anti‐inflammatory drugs represent one of the most popularly used classes of
drugs. However, their long‐term administration is associated with various side effects …

Complement system plays a dual role; physiological as well as pathophysiological. While
physiological role protects the host, pathophysiological role can substantially harm the host …

Abstract Complement activation and Rab GTPase trafficking are commonly observed in
inflammatory responses. Recruitment of innate immune cells to sites of infection or injury …

The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we
present a protocol to screen the effects of different agonists and antagonists on these …

Cerebral ischemia-reperfusion injury (CIRI), a prevalent stroke-related complication, can
lead to severe brain damage. Inflammation is a crucial factor in CIRI pathogenesis, and the …