Propagative isatin in organic synthesis of spirooxindoles through catalysis
Abstract Oxindole (indoline-2, 3-dione) has been utilized to a great extent in heterocyclic
scaffold syntheses as a futuristic medication and is considered a prominent building block …
scaffold syntheses as a futuristic medication and is considered a prominent building block …
[HTML][HTML] Microwave-assisted synthesis, antioxidant activity, docking simulation, and DFT analysis of different heterocyclic compounds
In this investigation, pressure microwave irradiation was used to clarify the activity of 1-(2-
hydroxyphenyl)-3-(4-methylphenyl) prop-2-en-1-one (3) towards several active methylene …
hydroxyphenyl)-3-(4-methylphenyl) prop-2-en-1-one (3) towards several active methylene …
[HTML][HTML] Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis
Q Wang, N Liu, Y Deng, Y Guan, H Xiao… - Nature …, 2023 - nature.com
Monensin A is a prototypical natural polyether polyketide antibiotic. It acts by binding a metal
cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A …
cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A …
Chiral Selenium Nanotherapeutics Regulates Selenoproteins to Attenuate Glucocorticoid‐Induced Osteoporosis
Z Xiong, H Lin, H Li, B Zou, B Xie, Y Yu… - Advanced Functional …, 2023 - Wiley Online Library
Abstract Glucocorticoid (GC)‐induced osteoporosis (GIO) is a concurrent disease commonly
appeared in chronic inflammatory and autoimmune disease patients. Stereoselective …
appeared in chronic inflammatory and autoimmune disease patients. Stereoselective …
Antimicrobial, antioxidant, mechanistic, docking simulation, and electrochemical studies for grafting polymerization of novel sulphonated gelatin derived from chicken …
MS Hashem, HS Magar, AM Fahim, RA Sobh - Materials Chemistry and …, 2023 - Elsevier
In this elucidation, alternative collagen sources were investigated. Chicken foot waste is one
of the alternate sources due to its high collagen protein concentration. Herein, high-quality …
of the alternate sources due to its high collagen protein concentration. Herein, high-quality …
[HTML][HTML] Novel functionalized spiro [Indoline-3, 5′-pyrroline]-2, 2′ dione derivatives: synthesis, characterization, drug-likeness, ADME, and anticancer potential
A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …
novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs)(4a–4h). Synthesized SOXs …
[HTML][HTML] Exploring the synthetic potential of epoxide ring opening reactions toward the synthesis of alkaloids and terpenoids: a review
Epoxides are oxygen containing heterocycles which are significantly employed as crucial
intermediates in various organic transformations. They are considered highly reactive three …
intermediates in various organic transformations. They are considered highly reactive three …
Flavin-Dependent Monooxygenase-Mediated 1,2-Oxazine Construction via Meisenheimer Rearrangement in the Biosynthesis of Paeciloxazine
D Yan, K Wang, S Bai, B Liu, J Bai, X Qi… - Journal of the American …, 2022 - ACS Publications
The [1, 2]-Meisenheimer rearrangement is well known as the [1, 2]-migration of an O-
substituted hydroxylamine from a tertiary amine N-oxide, and it is frequently employed in …
substituted hydroxylamine from a tertiary amine N-oxide, and it is frequently employed in …
[HTML][HTML] Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold
TAM Nguyen, D Grzech, K Chung, Z Xia… - Frontiers in Plant …, 2023 - frontiersin.org
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a
heterocyclic moiety. These compounds display an extensive range of biological activities …
heterocyclic moiety. These compounds display an extensive range of biological activities …
[HTML][HTML] Electrochemical oxidative rearrangement of tetrahydro-β-carbolines in a zero-gap flow cell
Y Zheng, YT Cheung, L Liang, H Qiu, L Zhang… - Chemical …, 2022 - pubs.rsc.org
Oxidative rearrangement of tetrahydro-β-carbolines (THβCs) is one of the most efficient
methods for the synthesis of biologically active spirooxindoles, including natural products …
methods for the synthesis of biologically active spirooxindoles, including natural products …