In trypanosomes, all RNAs are processed by the concerted action of trans-splicing and
polyadenylation. In trans-splicing, a common spliced leader (SL) is donated to all mRNAs …

Trypanosomatids are early-diverged, protistan parasites of which Trypanosoma brucei,
Trypanosoma cruzi, and several species of Leishmania cause severe, often lethal diseases …

In mammalians and yeast, the splicing factor U2 AF 65/Mud2p functions in precursor
messenger RNA (pre‐mRNA) processing. Arabidopsis AtU2 AF 65b encodes a putative U2 …

Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and
cause economically devastating diseases of livestock, and the few existing drugs have …

Trypanosomatid genomes encode for numerous proteins containing an RNA recognition
motif (RRM), but the function of most of these proteins in mRNA metabolism is currently …

In-depth analysis of the transcriptomes of several model organisms has revealed that
genomes are pervasively transcribed, giving rise to an abundance of non-canonical and …

Trypanosomes are protozoan parasites that cycle between a mammalian host (bloodstream
form) and an insect host, the Tsetse fly (procyclic stage). In trypanosomes, all mRNAs are …

Gene expression in trypanosomes is mainly regulated post-transcriptionally. Genes are
transcribed as polycistronic mRNAs that are dissected by the concerted action of trans …

In trypanosomatids, all mRNAs are processed via trans-splicing, although cis-splicing also
occurs. In trans-splicing, a common small exon, the spliced leader (SL), which is derived …

Allelic exclusion of variant surface glycoprotein (VSG) genes is essential for African
trypanosomes to evade the host antibody response by antigenic variation. The mechanisms …