Minamata disease in Japan and the large-scale poisoning by methylmercury (MeHg) in Iraq
caused wide public concerns about the risk emanating from mercury for human health …

Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …

The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …

Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …

Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple
pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron …

Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …

Neurodegeneration is a broadly defined term that describes the loss of neuronal structure
and function, and produces disorders known as neurodegenerative diseases. A common …

Neurological disorders are common, costly, and can cause enduring disability. Although
mostly unknown, a few environmental toxicants are recognized causes of neurological …

Introduction: There is increasing evidence that the pathophysiological target of mercury is in
fact selenium, rather than the covalent binding of mercury to sulfur in the body's ubiquitous …

Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …