During the past two decades, studies describing the chemistry and biology of PAF have
been extensive. This potent phosphoacylglycerol exhibits a wide variety of physiological and …

In recent years, knowledge of the physiology and pharmacology of hepatic circulation has
grown rapidly. Liver microcirculation has a unique design that allows very efficient exchange …

The synthesis of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-
phosphocholine) in rat brain was evaluated. Extracted PAF was characterized using …

Publisher Summary The chapter presents a study on platelet-activating factor (PAF)
acetylhydrolase from human plasma. Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero …

Conditioned media of isolated Kupffer and endothelial liver cells were added to incubations
of parenchymal liver cells, in order to test whether secretory products of Kupffer and …

Endothelin, a potent vasoactive peptide originally isolated from the vascular endothelial
cells, exerts glycogenolytic and vasoconstrictive actions in the perfused rat liver. In this …

Infusion of the thromboxane A2 analogue U-46619 into isolated perfused rat livers resulted
in dose-dependent increases in glucose output and portal vein pressure, indicative of …

Infusion of platelet-activating factor (alkyl acetylglycerophosphocholine (AGEPC] into
isolated perfused rat livers caused a dose-dependent, transient increase in portal vein …

Parenchymal cells (hepatocytes) are the sites at which the principal metabolic functions of
the liver are located. In the perfused liver, responses (eg vasoconstriction and …

Ligand binding studies demonstrated that isolated rat Kupffer cells possess high affinity
binding sites for platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine …