Clinically acquired resistance is a major challenge in cancer therapies with small-molecule
kinase inhibitors (SMKIs). Gatekeeper mutations in the ATP-binding pocket of kinases are …

Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …

Medullary thyroid carcinoma (MTC) is a neuroendocrine malignant tumor originating from
parafollicular C-cells producing calcitonin. Most of cases (75%) are sporadic while the …

Aberrant activation of the RET proto-oncogene is implicated in a plethora of cancers. RET
gain-of-function point mutations are driver events in multiple endocrine neoplasia 2 (MEN2) …

Over the past decades, the role of rearranged during transfection (RET) alterations in
tumorigenesis has been firmly established. RET kinase inhibition is an essential therapeutic …

Kinases are among the most important families of biomolecules and play an essential role in
the regulation of cell proliferation, apoptosis, metabolism, and other critical physiological …

The piperazine moiety is often found in drugs or in bioactive molecules. This widespread
presence is due to different possible roles depending on the position in the molecule and on …

Purpose: Rearranged during transfection (RET) aberrations represent a targetable
oncogene in several tumor types, with RET inhibitors displaying marked efficacy. However …

Lung cancer is still the leading cause of cancer-related mortality. Over the past two decades,
the management of non-small cell lung cancer (NSCLC) has undergone a significant …

Objective RET (rearranged during transfection) kinase, as a transmembrane receptor
tyrosine kinase, is a therapeutic target for several human cancer such as non-small cell lung …