The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in
various context-dependent ways, including increased metastatic potential, expansion of …

Netrin-1 and its receptors DCC (deleted in colorectal cancer) and the UNC5 orthologues
(human UNC5A–D and rodent UNC5H1–4) define a new mechanism for both the positive …

Mechanisms controlling brain size include the regulation of neural progenitor cell
proliferation, differentiation, survival and migration,. Here we show that ephrin-A/EphA …

During the development of the nervous system, neurons respond to the coordinated action
of a variety of attractive and repulsive signals from the embryonic environment. Netrins form …

Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …

The melanoma antigen (MAGE) proteins all contain a MAGE homology domain. MAGE
genes are conserved in all eukaryotes and have expanded from a single gene in lower …

The neurotrophin receptor p75 (p75 NTR), is involved in a diverse array of cellular
responses, including apoptosis, neurite outgrowth and myelination. Stimulation of p75 NTR …

Netrin‐1 receptors UNC5H (UNC5H1–4) were originally proposed to mediate the
chemorepulsive activity of netrin‐1 during axonal guidance processes. However, UNC5H …

Detachment of epithelial cells from matrix or attachment to an inappropriate matrix engages
an apoptotic response known as anoikis, which prevents metastasis. Cellular sensitivity to …

Background Netrin-1 may promote colorectal and breast tumorigenesis, by inhibiting
apoptosis induced by its dependence receptors, deleted in colorectal cancer (DCC) and …