Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …

Some cancers originate from a single mutation event in a single cell. Blood cancers known
as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is …

The sequencing and comparative analysis of a collection of bacterial genomes from a single
species or lineage of interest can lead to key insights into its evolution, ecology or …

Phylodynamics requires an interdisciplinary understanding of phylogenetics, epidemiology,
and statistical inference. It has also experienced more intense application than ever before …

Highlights•Using acquired somatic mutations as a genetic barcode allows reconstruction of
a stem cell “family tree” of relatedness.•Understanding HSC clonal dynamics is central to …

Mapping the cell phylogeny of a complex multicellular organism relies on somatic mutations
accumulated from zygote to adult. Available cell barcoding methods can record about three …

Nonparametric population genetic modeling provides a simple and flexible approach for
studying demographic history and epidemic dynamics using pathogen sequence data …

Livestock farming across the world is constantly threatened by the evolutionary turnover of
foot-and-mouth disease virus (FMDV) strains in endemic systems, the underlying dynamics …

Genealogical tree modeling is essential for estimating evolutionary parameters in population
genetics and phylogenetics. Recent mathematical results concerning ranked genealogies …