Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which is involved in …

In this study we analyzed the expression levels of markers of epithelial-to-mesenchymal
transition (EMT) in several papillary thyroid carcinomas (PTCs) and the relation with tumor …

Many reports indicate that the protective action of nutraceuticals in the Mediterranean diet,
against metabolic and cardiovascular diseases, can be attributed to the action of …

Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are
widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension …

Sildenafil is an approved drug for the treatment of erectile dysfunction. The drug exerts its
action through the relaxation of smooth muscles and the modulation of vascular endothelial …

Abstract Cyclic nucleotide phosphodiesterase 5 (PDE5) has been recently identified to play
a crucial role in the progression of many cancers. PDE5 promotes tumorigenesis by …

Purpose: By catalyzing cGMP hydrolysis, phosphodiesterase (PDE) 5 is a critical regulator of
its concentration and effects in different (patho) physiologic processes, including cancers. As …

The overexpression of phosphodiesterase (PDE) 5 is frequently found in various human
cancers, such as those of the breast. However, PDE5's role in the tumor microenvironment is …

Cancers are an extraordinarily heterogeneous collection of diseases with distinct genetic
profiles and biological features that directly influence response patterns to various treatment …