Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …

Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles
originating from different cell compartments. EVs participate in many essential physiological …

Spontaneous preterm birth (PTB) and preterm pre-labor rupture of the membranes (pPROM)
are major pregnancy complications. Although PTB and pPROM have common etiologies …

The signals and mechanisms that synchronize the timing of human parturition remain a
mystery and a better understanding of these processes is essential to avert adverse …

Healthy pregnancy is the most successful form of graft tolerance, whereas preterm labor
(PTL) may represent a breakdown in maternal-fetal tolerance. Although maternal immune …

Endocrine factors and signals of fetal organ maturation are reported determinants of birth
timing. To test the hypothesis that paracrine signaling by exosomes are key regulators of …

Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

Exosomes are membrane-bound nanovesicles that transport molecular signals between
cells. This study determined changes in maternal plasma exosome proteomics contents in …

The steroid hormones progesterone (P4) and estradiol-17β (E2), produced by the placenta
in humans and the ovaries in rodents, serve crucial roles in the maintenance of pregnancy …