The calcium pump (aka Ca 2+-ATPase or SERCA) is a membrane transport protein
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …

Single-span transmembrane (TM) helices have structural and functional roles well beyond
serving as mere anchors to tether water-soluble domains in the vicinity of the membrane …

Protein–protein interactions within the membrane are involved in many vital cellular
processes. Consequently, deficient oligomerization is associated with known diseases. The …

In muscle cells, the sarcoplasmic reticulum (SR) not only acts as a Ca2+ store, but also
regulates the contractile characteristics of the muscle. Ca2+ release from the SR is the …

α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …

Membrane proteins play the central roles in a variety of cellular processes, ranging from
nutrient uptake and signalling, to cell-cell communication. Their biological functions are …

The sarco (endo) plasmic reticulum calcium ATPase (SERCA) is regulated in a tissue-
dependent manner via interaction with the short integral membrane proteins …

The physicochemical properties of the lipid bilayer shape the structure and topology of
membrane proteins and regulate their biological function. Here, we investigated the …

The interaction of phospholamban (PLN) with the sarco-endoplasmic reticulum Ca 2+-
ATPase (SERCA) pump is a major regulatory axis in cardiac muscle contractility. The …

Calcium is a universal second messenger involved in diverse cellular processes, including
excitation-contraction coupling in muscle. The contraction and relaxation of cardiac muscle …