Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

The first guidance on Good Cell Culture Practice (GCCP) dates back to 2005. This document
expands this to include aspects of quality assurance for in vitro cell culture focusing on the …

Human pluripotent stem cells (hPSCs) represent a promising cell source for the
development of β-cells for use in therapies for type 1 diabetes. Current culture approaches …

Stem cells having the capability to differentiate into other type of cells and renewing
themselves, gained so much importance in recent years. Investigations in stem cells …

Bioengineering approaches to regulate stem cell fates aim to recapitulate the in vivo
microenvironment. In recent years, manipulating the micro-and nano-scale topography of …

Эффективным методом лечения инсулинозависимого сахарного диабета,
альтернативным гормонозаместительной терапии, является трансплантация инсулин …

Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows
diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze …

Islets transplantation represents a potential therapy for diabetes mellitus type 1. To date,
transplantation is limited by the poor viability of islets in vitro. In this study, we use agarose …

Background: For years, scientists have been striving to identify compounds to improve the
characteristics and functions of cells for therapeutic applications. Objectives: This study …

Objectives Embryonic stem cells (ESCs)–derived pancreatic precursor cells have great
potential for pancreas repair. Expression of pancreatic duodenal homeobox 1 (Pdx1) in …