Over the last few decades, advances in human and animal‐based techniques have greatly
enhanced our understanding of the neural mechanisms underlying psychiatric disorders …

Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

Despite our ever-changing environment, animals are remarkably adept at selecting courses
of action that are predictive of optimal outcomes. While requiring the contribution of a …

Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as
PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism …

Schizophrenia has been studied from the perspective of cognitive or reward-related
impairments, yet it cannot be wholly related to one or the other process and their …

Patients with schizophrenia are at an increased risk for the development of depression.
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …

Abstract Disrupted-in-schizophrenia 1 (DISC1) is a mental illness gene first identified in a
Scottish pedigree. So far, DISC1-dependent phenotypes in animal models have been …

Guided by features of molecular, cellular, and circuit dysfunction affecting the prefrontal
cortex in clinical investigations, we targeted prefrontal cortex in studies of a model for …

Neuregulin (NRG) and its cognate neuronal receptor tyrosine kinase ErbB4 are genetically
associated with increased risk for schizophrenia and its endophenotyes. 1–4 Moreover …

We have seen an era of explosive progress in translating neurobiology into etiological
understanding of mental disorders for the past 10–15 years. The discovery of Disrupted-in …