Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges

M Asmamaw Mengstie - Frontiers in Bioengineering and …, 2022 - frontiersin.org
The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and its
accompanying protein (Cas9) are now the most effective, efficient, and precise genome …

Genome editing for cystic fibrosis

G Wang - Cells, 2023 - mdpi.com
Cystic fibrosis (CF) is a monogenic recessive genetic disorder caused by mutations in the
CF Transmembrane-conductance Regulator gene (CFTR). Remarkable progress in basic …

[PDF][PDF] Next-Generation strategies to combat antimicrobial resistance: Integrating genomics, CRISPR, and novel therapeutics for effective treatment

AO Olatunji, JA Olaboye, CC Maha… - … & Technology Journal, 2024 - researchgate.net
Olatunji, Olaboye, Maha, KOlawole, & Abdul, P. No. 2284-2303 Page 2285 therapy, and
synthetic biology-derived compounds, provides alternative treatment options. These …

Down-regulated miR-146a expression with increased neutrophil extracellular traps and apoptosis formation in autoimmune-mediated diffuse alveolar hemorrhage

YT Hsieh, YC Chou, PY Kuo, HW Tsai, YT Yen… - Journal of biomedical …, 2022 - Springer
Background Increasing evidences have suggested an important role of microRNAs
(miRNAs) in regulating cell death processes including NETosis and apoptosis. Dysregulated …

Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles

X Huang, A Li, P Xu, Y Yu, S Li, L Hu… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) have emerged as a promising platform for gene delivery owing
to their natural properties and phenomenal functions, being able to circumvent the …

The CRISPR/Cas system: a customizable toolbox for molecular detection

Y He, W Yan, L Long, L Dong, Y Ma, C Li, Y Xie, N Liu… - Genes, 2023 - mdpi.com
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated
proteins (Cas) are promising molecular diagnostic tools for rapidly and precisely elucidating …

An orthogonally activatable CRISPR-Cas13d nanoprodrug to reverse chemoresistance for enhanced chemo-photodynamic therapy

Z Liu, Z Feng, M Chen, J Zhan, R Wu, Y Shi, Y Xue… - Chemical …, 2023 - pubs.rsc.org
Orthogonal therapy that combines CRISPR-based gene editing and prodrug-based
chemotherapy is a promising approach to combat multidrug-resistant cancer. However, its …

RNA-dependent RNA targeting by CRISPR-cas systems: characterizations and applications

N Gunitseva, M Evteeva, A Borisova… - International Journal of …, 2023 - mdpi.com
Genome editing technologies that are currently available and described have a fundamental
impact on the development of molecular biology and medicine, industrial and agricultural …

CRISPR-based genome editing tools: an accelerator in crop breeding for a changing future

F Zhang, TX Neik, WJW Thomas, J Batley - International journal of …, 2023 - mdpi.com
Genome editing is an important strategy to maintain global food security and achieve
sustainable agricultural development. Among all genome editing tools, CRISPR-Cas is …

Rapid, sensitive, and visual detection of swine Japanese encephalitis virus with a one-pot RPA-CRISPR/EsCas13d-based dual readout portable platform

D You, T Xu, BZ Huang, L Zhu, F Wu, LS Deng… - International Journal of …, 2024 - Elsevier
Japanese encephalitis (JE), a mosquito-borne zoonotic disease caused by the Japanese
encephalitis virus (JEV), poses a serious threat to global public health. The low viremia …